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Title Abstract Screening Made Easy
Review duplicates and screen studies efficiently with AI suggestions
Comparative Effectiveness of GLP-1 Receptor Agonists vs DPP-4 Inhibitors in Type 2 Diabetes: A Systematic Review and Meta-Analysis
Martinez R, Chen L, Okafor K · Diabetes Care (2024)
Abstract
Background: This systematic review compared the clinical effectiveness of GLP-1 receptor agonists with DPP-4 inhibitors in adults with type 2 diabetes mellitus.
Methods: Thirty-four randomised controlled trials (n=28,042) were included. Eligible studies enrolled adults with type 2 diabetes receiving GLP-1 agonists or DPP-4 inhibitors for ≥12 weeks.
Results: GLP-1 agonists demonstrated superior HbA1c reduction (−0.4%, 95% CI −0.5 to −0.3) and significant weight loss compared with DPP-4 inhibitors.
Rationale
Study compares two pharmacological interventions for T2D management with clinical outcomes. Meets population, intervention, and outcome criteria per protocol.
PICOS Extraction
Adults with Type 2 Diabetes
GLP-1 receptor agonists
DPP-4 inhibitors
HbA1c, cardiovascular events
Randomized controlled trial
Full-Text Screening with AI-Enabled PICOS
Streamline your full-text screening process using AI-powered PICOS extraction
Methods
Study Design: This multi-centre randomized controlled trial was conducted across 24 clinical sites in North America and Europe between January 2021 and December 2023.
Participants: We enrolled 1,842 adults aged 30–75 with confirmed type 2 diabetes and inadequate glycemic control (HbA1c 7.5–11.0%) on metformin monotherapy. Key exclusion criteria included renal impairment (eGFR <30), prior GLP-1RA use, and active cardiovascular disease.
Intervention: Participants were randomized 1:1 to semaglutide 1.0 mg weekly or standard of care for 52 weeks. The primary endpoint was change in HbA1c from baseline at week 52.
Rationale
RCT comparing GLP-1RA vs standard of care in T2D population with HbA1c and cardiovascular endpoints. Meets all eligibility criteria per protocol.
PICOS Extraction
Adults with Type 2 Diabetes
GLP-1 receptor agonists
Standard of care
HbA1c, weight, cardiovascular events
Randomized controlled trial
Automated Data Extraction
Automatically extract key data from studies and link it to highlighted sources for easy verification with our AI-powered tool.
Effects of Metformin on Glycemic Control in Adults with Type 2 Diabetes: A Multi-Centre Study
Johnson A, Smith B, Patel C, Williams D
Journal of Clinical Endocrinology & Metabolism, Vol 109 (3), 2024
Abstract
Background: This randomized controlled trial1 evaluated the efficacy of metformin monotherapy in newly diagnosed patients with type 2 diabetes across 12 clinical sites in North America and Europe.
Methods: A total of 245 adults aged 18–65 with confirmed type 2 diabetes2 were enrolled and randomized 1:1 to metformin 1 000 mg daily or matched placebo for 12 weeks. The primary endpoint was change in HbA1c from baseline.
Results: The primary endpoint of HbA1c reduction at 12 weeks3 showed significant improvement in the treatment group (−1.2% vs −0.3%, p<0.001). Secondary endpoints including fasting glucose and body weight also favoured metformin.
Study Design
Randomized Controlled Trial
Sample Size
245 participants
Population
Adults 18–65, Type 2 Diabetes
Primary Outcome
HbA1c reduction at 12 wk
Empowering Researchers to Deliver Excellence
Conduct systematic reviews with our AI-powered platform, designed to help you achieve your research goals.
Create custom extraction forms, define protocols, leverage AI and set up workflows that align precisely with your project requirements.
Enhance your systematic review with our AI assistant. Functioning as both a proactive Copilot during the screening and data extraction stages, and as an Independent Reviewer alongside human experts.
Collaborate seamlessly with your team on a centralized platform. Assign roles, track progress, and communicate effectively.
Efficiently and precisely extract key information from studies, automatically linked to highlighted sources for easy verification.
Access the full text of studies instantly with just a single click.
Resolve disagreements among reviewers with ease. Manage consensus and maintain the integrity of your systematic review.
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